This work was supported by the Bill & Melinda Gates Foundation (grant OPP113634) and by National Institutes of Health (grant K23 MH099916).
The Journal of Infectious Diseases
Antiretroviral therapy -- Studies
Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/μL) or late-stage disease (CD4 T-cell count <200/ μL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in latestage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.
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Siedner, Mark J.; Bwana, Bosco M.; Asiimwe, Stephen; Amanyire, Gideon; Musinguzi, Nicholas; Castillo-Mancilla, Jose R.; Tracy, Russell P.; Katz, Ingrid T.; Bangsberg, David; and multiple additional authors, "Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study" (2019). OHSU-PSU School of Public Health Faculty Publications and Presentations. 221.