The Treatment Ambassador Program: A Highly Acceptable and Feasible Community-Based Peer Intervention for South Africans Living with HIV Who Delay or Discontinue Antiretroviral Therapy.
National Institute of Health (NIH); Institute: National Institute of Mental Health (NIMH); Type: Planning Grant (R34). Project #: 5R34MH108393-02. Dr. Bogart was additionally support by P30MH058107. Dr. Bassett was supported to this work by a K24AI141036 grant from the NIH. The study can be referenced on Clinicaltrials.gov under the unique identifier NCT03099707.
AIDS and Behavior
We conducted a novel pilot randomized controlled trial of the Treatment Ambassador Program (TAP), an 8-session, peer-based, behavioral intervention for people with HIV (PWH) in South Africa not on antiretroviral therapy (ART). PWH (43 intervention, 41 controls) completed baseline, 3- and 6-month assessments. TAP was highly feasible (90% completion), with peer counselors demonstrating good intervention fidelity. Post-intervention interviews showed high acceptability of TAP and counselors, who supported autonomy, assisted with clinical navigation, and provided psychosocial support. Intention-to-treat analyses indicated increased ART initiation by 3 months in the intervention vs. control arm (12.2% [5/41] vs. 2.3% [1/43], Fisher exact p-value = 0.105; Cohen's h = 0.41). Among those previously on ART (off for > 6 months), 33.3% initiated ART by 3 months in the intervention vs. 14.3% in the control arm (Cohen's h = 0.45). Results suggest that TAP was highly acceptable and feasible among PWH not on ART.
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Katz, I. T., Bogart, L. M., Fitzmaurice, G. M., Staggs, V. S., Gwadz, M. V., Bassett, I. V., Cross, A., Courtney, I., Tsolekile, L., Panda, R., Steck, S., Bangsberg, D. R., Orrell, C., & Goggin, K. (2020). The Treatment Ambassador Program: A Highly Acceptable and Feasible Community-Based Peer Intervention for South Africans Living with HIV Who Delay or Discontinue Antiretroviral Therapy. AIDS and Behavior. https://doi.org/10.1007/s10461-020-03063-1