Extreme Sawtooth-Sign in Motor Neuron Disease (MND) Suggests Laryngeal Resistance to Forced Expiratory Airflow
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The OHSU Biostatistics & Design Program data analysis expertise for this project was partially supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR002369.
The Annals of Otology, Rhinology, and Laryngology
The impact of laryngeal dysfunction on airflow has not been well characterized in motor neuron disease (MND). This study aimed to detect and characterize extreme airflow oscillations informally observed during volitional cough and forced vital capacity (FVC) tasks in individuals with MND who demonstrated neurolaryngeal impairments including reduced speed and extent of vocal fold abduction compared to healthy controls during volitional cough expulsion. The extreme airflow oscillations in the MND group, when viewed as a flow-volume loop, appeared similar to the "sawtooth-sign." If the airflow oscillations are periodic in a range similar to phonation, they may reflect reduced laryngeal patency.
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Britton, D., Kain, A., Chen, Y. W., Wiedrick, J., Benditt, J. O., Merati, A. L., & Graville, D. (2022). Extreme Sawtooth-Sign in Motor Neuron Disease (MND) suggests Laryngeal Resistance to Forced Expiratory Airflow. Annals of Otology, Rhinology & Laryngology, 00034894221089407.