Title of Poster / Presentation
A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different VDR4 High Frequency Percussive Ventilator (HPFV) Circuits
Presentation Type
Poster
Location
Portland State University
Start Date
5-12-2015 11:00 AM
End Date
5-12-2015 1:00 PM
Subjects
Respiration therapy, Inhalation Administration
Abstract
The purpose of this study was to determine if the positioning of a nebulizer at two different locations in the VDR4, a specialty ventilator, would result in differing dose administrations of a bronchodilator, Albuterol Sulfate. We hypothesized that placement near the endotracheal tube will provide greater dose deposition. The ventilator was set up to mimic the normal adult patient. Administration was done through the nebulizer placed in the ventilator circuit either before the humidifier or between the endotracheal tube and the VDR 4’s Phasitron. Three trials were performed using a standard dose of Albuterol for each trial. The mass of the delivered dose was measured via UV spectrophotometry and the percent dose delivered was calculated. With the double limb circuit, the deposition to the end of the endotracheal tube was greater when the nebulizer was placed before the humidifier (8.6%), rather than near the endotracheal tube (5.2%). The single limb circuit showed contrasting results, with greater deposition when the nebulizer was placed near the endotracheal tube (3.65%), as compared to the placement pre-humidifier (2.62%). Particle size was shown to be at 4.6-4.9 VMD. Maximal dose was achieved between the two circuits when the Aerogen was placed before the humidifier using the double limb circuit. In contrary to our expectations, data showed medication delivery was greater when the nebulizer was placed before the humidifier in the double limb circuit. We hypothesize now that releasing the medication into the circuit where the air is already saturated with water may possibly decrease the uptake of medication.
Rights
© Copyright the author(s)
IN COPYRIGHT:
http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
DISCLAIMER:
The purpose of this statement is to help the public understand how this Item may be used. When there is a (non-standard) License or contract that governs re-use of the associated Item, this statement only summarizes the effects of some of its terms. It is not a License, and should not be used to license your Work. To license your own Work, use a License offered at https://creativecommons.org/
Persistent Identifier
http://archives.pdx.edu/ds/psu/19818
A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different VDR4 High Frequency Percussive Ventilator (HPFV) Circuits
Portland State University
The purpose of this study was to determine if the positioning of a nebulizer at two different locations in the VDR4, a specialty ventilator, would result in differing dose administrations of a bronchodilator, Albuterol Sulfate. We hypothesized that placement near the endotracheal tube will provide greater dose deposition. The ventilator was set up to mimic the normal adult patient. Administration was done through the nebulizer placed in the ventilator circuit either before the humidifier or between the endotracheal tube and the VDR 4’s Phasitron. Three trials were performed using a standard dose of Albuterol for each trial. The mass of the delivered dose was measured via UV spectrophotometry and the percent dose delivered was calculated. With the double limb circuit, the deposition to the end of the endotracheal tube was greater when the nebulizer was placed before the humidifier (8.6%), rather than near the endotracheal tube (5.2%). The single limb circuit showed contrasting results, with greater deposition when the nebulizer was placed near the endotracheal tube (3.65%), as compared to the placement pre-humidifier (2.62%). Particle size was shown to be at 4.6-4.9 VMD. Maximal dose was achieved between the two circuits when the Aerogen was placed before the humidifier using the double limb circuit. In contrary to our expectations, data showed medication delivery was greater when the nebulizer was placed before the humidifier in the double limb circuit. We hypothesize now that releasing the medication into the circuit where the air is already saturated with water may possibly decrease the uptake of medication.