Proteins -- Structure -- Computer simulation, Septic shock, Septicemia, Biology -- Computer simulation
Recent studies describe computer simulation models of the acute or systemic inflammatory response (AIR or SIR) to severe sepsis, a condition that can lead to multiple organ failure and death. One study used an agent-based model, while the other used differential equations (DEs) to simulate a randomized clinical trial. Both studies obtained results similar to the actual results from a successful clinical drug trial of severe sepsis, suggesting that in silico (simulated) randomized clinical trials may be used to design more effective in vivo clinical trials.
Wakeland, W., Fusion, J., and Goldstein, B. (2006). Reproducing Published Results from In Silico Computer Models of the Acute Inflammatory Response to Severe Sepsis. Poster presentation at the International Conference on Complexity in Acute Illness (ICCAI), in Washington D.C.