Date of Award
Mathematics and Statistics
Retinal degeneration, Multiple sclerosis, Nervous system -- Degeneration
Patients with multiple sclerosis (MS) have long been known to suffer deterioration of the retina, sometimes leading to blindness. The damage has been assumed to occur predominantly within the retinal nerve fiber layer. Using optical coherence tomography (OCT), researchers at Johns Hopkins University have determined that there is a subset of MS patients for whom the retinal deterioration is different. For this group the deterioration occurs at a deeper level within the retina, between the photoreceptors and the connecting cells. This deterioration affects the inner and outer nuclear layers of the retina. These findings are perplexing, as MS is considered primarily a demyelinating disease, and the retinal cell structures are unmyelinated.
Festner, Zac, "Understanding Multiple Sclerosis Through Retinal Cell Layer Thickness: An Insight into the Neurodegeneration Process" (2016). University Honors Theses. Paper 245.