Date of Award

2016

Document Type

Thesis

Department

Mathematics and Statistics

First Advisor

Jong Kim

Subjects

Retinal degeneration, Multiple sclerosis, Nervous system -- Degeneration

DOI

10.15760/honors.235

Abstract

Patients with multiple sclerosis (MS) have long been known to suffer deterioration of the retina, sometimes leading to blindness. The damage has been assumed to occur predominantly within the retinal nerve fiber layer. Using optical coherence tomography (OCT), researchers at Johns Hopkins University have determined that there is a subset of MS patients for whom the retinal deterioration is different. For this group the deterioration occurs at a deeper level within the retina, between the photoreceptors and the connecting cells. This deterioration affects the inner and outer nuclear layers of the retina. These findings are perplexing, as MS is considered primarily a demyelinating disease, and the retinal cell structures are unmyelinated.

Comments

An undergraduate honors thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Arts in University Honors and Mathematics

Persistent Identifier

http://archives.pdx.edu/ds/psu/17308

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