Uv-Induced DNA Damage Disrupts the Coordination Between Replication Initiation, Elongation, and Completion.
Sponsor
National Science Foundation. Grant Number: MCB1916625
Published In
Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Document Type
Citation
Publication Date
12-31-2020
Abstract
Replication initiation, elongation, and completion are tightly coordinated to ensure that all sequences replicate precisely once each generation. UV-induced DNA damage disrupts replication and delays elongation, which may compromise this coordination leading to genome instability and cell death. Here, we profiled the Escherichia coli genome as it recovers from UV irradiation to determine how these replicational processes respond. We show that oriC initiations continue to occur, leading to copy number enrichments in this region. At late times, the combination of new oriC initiations and delayed elongating forks converging in the terminus appear to stress or impair the completion reaction, leading to a transient over-replication in this region of the chromosome. In mutants impaired for restoring elongation, including recA, recF, and uvrA, the genome degrades or remains static, suggesting that cell death occurs early after replication is disrupted, leaving partially duplicated genomes. In mutants impaired for completing replication, including recBC, sbcCD xonA, and recG, the recovery of elongation and initiation leads to a bottleneck, where the non-terminus region of the genome is amplified and accumulates, indicating that a delayed cell death occurs in these mutants, likely resulting from mis-segregation of unbalanced or unresolved chromosomes when cells divide.
Rights
© 2020 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd
Locate the Document
DOI
10.1111/gtc.12826
Persistent Identifier
https://archives.pdx.edu/ds/psu/35209
Citation Details
Wendel, B. M., Hollingsworth, S., Courcelle, C. T., & Courcelle, J. (2021). UV‐induced DNA damage disrupts the coordination between replication initiation, elongation and completion. Genes to Cells, 26(2), 94–108. https://doi.org/10.1111/gtc.12826