Sponsor
We thank the NIH and FDA for support of this work via award R01ES025257. Research reported in this publication was supported by NIEHS and FDA Center for Tobacco Products (CTP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Food and Drug Administration.
Published In
Scientific Reports
Document Type
Article
Publication Date
2-14-2017
Subjects
Electronic cigarettes -- Composition -- Analysis, Commercial products -- Testing, Toxological chemistry, Tobacco products -- Chemistry
Abstract
Knowledge of the mechanism of formation, levels and toxicological profiles of the chemical products in the aerosols (i.e., vapor plus particulate phases) of e-cigarettes is needed in order to better inform basic research as well as the general public, regulators, and industry. To date, studies of e-cigarette emissions have mainly focused on chromatographic techniques for quantifying and comparing the levels of selected e-cigarette aerosol components to those found in traditional cigarettes. E-cigarettes heat and aerosolize the solvents propylene glycol (PG) and glycerol (GLY), thereby affording unique product profiles as compared to traditional cigarettes. The chemical literature strongly suggests that there should be more compounds produced by PG and GLY than have been reported in e-cigarette aerosols to date. Herein we report an extensive investigation of the products derived from vaporizing PG and GLY under mild, single puff conditions. This has led to the discovery of several new compounds produced under vaping conditions. Prior reports on e-cigarette toxin production have emphasized temperature as the primary variable in solvent degradation. In the current study, the molecular pathways leading to enhanced PG/GLY reactivity are described, along with the most impactful chemical conditions promoting byproduct production.
DOI
10.1038/srep42549
Persistent Identifier
http://archives.pdx.edu/ds/psu/19491
Citation Details
Jensen, R. P., Strongin, R. M., & Peyton, D. H. (2017). Solvent chemistry in the electronic cigarette reaction vessel. Scientific Reports, 7.
Description
© The Author(s) 2017
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