Sponsor
This work was supported by the NIH NIGMS as a Maximizing Investigators’ Research Award, 1R35GM119839-01 (C.S.), NIH NIBIB 1R15EB021581-01 (G.S.), and Oregon State University College of Pharmacy Start-up Funds.
Published In
Nanoscale Research Letters
Document Type
Article
Publication Date
2018
Subjects
Nanoparticles -- Synthesis, nanocrystals, Iridium, Surfaces (Technology) -- Analysis, Biocompatibility
Abstract
High-density inorganic nanoparticles have shown promise in medical applications that utilize radiation including X-ray imaging and as radiation dose enhancers for radiotherapy. We have developed an aqueous synthetic method to produce small (~ 2 nm) iridium nanoparticles (IrNPs) by reduction of iridium(III) chloride using a borohydride reducing agent. Unlike other solution-based synthesis methods, uniform and monodispersed IrNPs are produced without the use of surfactants or other solubilizing ligands. These nanoparticles are highly crystalline as observed by X-ray diffraction and high-resolution transmission electron microscopy (TEM). In vitro metabolic toxicity assays using hepatocyte and macrophage cells demonstrate that both IrNPs and iridium(III) chloride are well tolerated at concentrations of up to 10 μM iridium. Furthermore, the IrNPs were assessed in a hemolytic assay and found to have no significant impact on red blood cells when exposed to concentrations up to 100 μM. Overall, these results support the potential for the in vivo application of this nanomaterial.
DOI
10.1186/s11671-018-2621-3
Persistent Identifier
https://archives.pdx.edu/ds/psu/29645
Citation Details
Brown, A. L., Winter, H., Goforth, A. M., Sahay, G., & Sun, C. (2018). Facile Synthesis of Ligand-Free Iridium Nanoparticles and Their In Vitro Biocompatibility. Nanoscale research letters, 13(1), 208.
Description
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.