Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by H-1 NMR Spectroscopy

Authors

Jiries Meehan-Atrash, Portland State UniversityFollow
Anna K. Duell, Portland State University
Kevin J. McWhirter, Portland State UniversityFollow
Wentai Luo, Portland State UniversityFollow
David H. Peyton, Portland State UniversityFollow
Robert M. Strongin, Portland State UniversityFollow

Sponsor

NIH and the FDA for support via award R01ES025257.

Published In

Chemical Research In Toxicology

Document Type

Citation

Publication Date

6-17-2019

Abstract

Heat-not-burn products, eg, I quit ordinary smoking (IQOS), are becoming popular alternative tobacco products. The nicotine aerosol protonation state has addiction implications due to differences in absorption kinetics and harshness. Nicotine free-base fraction (αfb) ranges from 0 to 1. Herein, we report αfb for IQOS aerosols by exchange-averaged 1H NMR chemical shifts of the nicotine methyl protons in bulk aerosol and verified by headspace-solid phase microextraction-gas chromatography-mass spectrometry. The αfb ≈ 0 for products tested; likely a result of proton transfer from acetic acid and/or other additives in the largely aqueous aerosol. Others reported higher αfb for these products, however, their methods were subject to error due to solvent perturbation.

Description

Copyright © 2019 American Chemical Society

Locate the Document

http://doi.org/10.1021/acs.chemrestox.9b00076

DOI

10.1021/acs.chemrestox.9b00076

Persistent Identifier

https://archives.pdx.edu/ds/psu/29357

Citation Details

Meehan-Atrash, J., Duell, A. K., McWhirter, K. J., Luo, W., Peyton, D. H., & Strongin, R. M. (2019). Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR Spectroscopy. Chemical Research In Toxicology, 32(6), 974–976.