Aggregation in Amphiphilic Macrocycle Substituted Gd3+ DOTA-type Chelates is Affected by the Regiochemistry of Substitution
Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.
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Webber, B. C., Cassino, C., Botta M.,, and Woods, M. (2015). Aggregation in Amphiphilic Macrocycle Substituted Gd3+ DOTA-type Chelates is Affected by the Regiochemistry of Substitution. Inorg. Chem., (2015), 54, 2085–2087.
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