Aggregation in Amphiphilic Macrocycle Substituted Gd3+ DOTA-type Chelates is Affected by the Regiochemistry of Substitution
Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.
Locate the Document
Webber, B. C., Cassino, C., Botta M.,, and Woods, M. (2015). Aggregation in Amphiphilic Macrocycle Substituted Gd3+ DOTA-type Chelates is Affected by the Regiochemistry of Substitution. Inorg. Chem., (2015), 54, 2085–2087.