Sponsor
The authors acknowledge grant support from the National Institutes of Health (EB‐11687 (M.W.); RR‐02584 and CA‐115531 (A.D.S.)); ONAMI (N00014–11–1–0193), the M. J. Murdock Charitable Trust and the Robert A Welch Foundation (AT‐584).
Published In
Chemistry
Document Type
Post-Print
Publication Date
9-2011
Subjects
Chelates -- Synthesis, Contrast media (Diagnostic imaging), Magnetic resonance imaging, Lanthanide shift reagents, Ligands (Biochemistry)
Abstract
LnDOTA-tetraamide chelates (DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) have received considerable recent attention as a result of their potential to act as PARACEST contrast agents for magnetic resonance imaging (MRI). Although PARACEST agents afford several advantages over conventional contrast agents they suffer from substantially higher detection limits; thus, improving the effectiveness of LnDOTA-tetraamide chelates is an important goal. In this study we investigate the potential to extend conformational control of LnDOTA-type ligands to those applicable to PARACEST. Furthermore, the question of whether δ- rather than α-substitution of the pendant arms could be used to control the chelate coordination geometry is addressed. Although δ-substitution does influence coordination geometry it does not afford control. However, it can play an important role in governing the conformation of the amide substituent relative to the chelate in such as way that suggests a PARACEST agent could be designed that has detection limits at least as low as a conventional MRI contrast agent.
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DOI
10.1002/chem.201101007
Persistent Identifier
https://archives.pdx.edu/ds/psu/31159
Citation Details
Published as: Carney, C. E., Tran, A. D., Wang, J., Schabel, M. C., Sherry, A. D., & Woods, M. (2011). Towards the rational design of MRI contrast agents: δ-substitution of lanthanide(III) NB-DOTA-tetraamide chelates influences but does not control coordination geometry. Chemistry (Weinheim An Der Bergstrasse, Germany), 17(37), 10372–10378. https://doi.org/10.1002/chem.201101007
Description
This is the author’s version of a work that was accepted for publication in Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemistry, 5;17(37):10372-8. doi: 10.1002/chem.201101007.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.