LDL-Based Nanoparticles for Contrast Enhanced MRI of Atheroplaques in Mouse Models

Authors

Yoko Yamakoshi, University of Pennsylvania
Hui Qiao, University of Pennsylvania
Andrew N. Lowell, University of Pennsylvania
Mark Woods, Portland State UniversityFollow
Betty Paulose, University of Pennsylvania
Yuka Nakao, University of Pennsylvania
Hualei Zhang, University of Pennsylvania
Ting Liu, University of Pennsylvania
Sissel Lund-Katz, The Children’s Hospital of Philadelphia
Rong Zhou, University of Pennsylvania

Published In

Chemical Communication

Document Type

Citation

Publication Date

2011

Abstract

A LDL particle functionalized with a GdDO3A-monoamidechelate with a long alkenyl anchor (GdDO3A-OA) was preparedforin vivodetection of atheroplaques. The GdDO3A-OA, whensuccessfully intercalated into the lipid layer of LDL particles, ledto a significant enhancement of magnetic resonance imaging signalintensity of atheroplaques in atherosclerosis mouse models.

Description

This journal is copyrighted The Royal Society of Chemistry 2011

Locate the Document

https://doi.org/10.1039/C1CC10924C

DOI

10.1039/C1CC10924C

Persistent Identifier

https://archives.pdx.edu/ds/psu/32343

Citation Details

Yamakoshi, Y., Qiao, H., Lowell, A. N., Woods, M., Paulose, B., Nakao, Y., Zhang, H., Liu, T., Lund-Katz, S., & Zhou, R. (2011). LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models. Chemical Communications (Cambridge, England), 47(31), 8835–8837.