Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents

Authors

Sally E. Plush, University of Texas Southwestern Medical CenterFollow
Mark Woods, Portland State UniversityFollow
You-Fu Zhou, University of Texas at DallasFollow
Shyam B. Kadali, Rice University
Michael S. Wong, Rice University
A. Dean Sherry, University of Texas at DallasFollow

Sponsor

The authors thank the National Institutes of Health (RR-02584, CA-126608, and CA-115531), the Robert A Welch Foundation (AT-584), 3M (NTF Award), the National Science Foundation (CBET-0652073), Portland State University, Oregon Opportunity, and the Kobayashi Graduate Student Fellowship (to S.B.K.) for financial assistance. We also thank both the MCIF and flow cytometry core facilities and Professor Gao’s research group at UT Southwestern Medical Center for valuable discussions.

Published In

Journal of the American Chemical Society

Document Type

Citation

Publication Date

2010

Abstract

Nanoassembled capsules (NACs) that incorporate a polymer aggregate inside a silica shell may be loaded with agents that are of particular interest for therapeutic or diagnostic applications. NACs formed using the MRI contrast agent GdDOTP⁵⁻ in the internal polymer aggregate are reported herein, the smaller of which show promise as potential MRI contrast agents. Unlike many other nanoencapsulated systems, water access to the inner core of these NACs does not appear to be limited and consequently the water relaxivity per Gd³⁺ agent can reach as high as 24 mM⁻¹ s⁻¹. Robust, spherical capsules were formed using polyallylamine or poly-l-lysine ranging from 0.2 to 5 μm in diameter. The greatest gains in relaxivity were observed for smaller NACs, for which water accessibility remained high but molecular rotation of the Gd³⁺ chelate was effectively restricted. Larger NACs did not afford such large gains in relaxivity, the result of poorer water accessibility combined with less-effective rotational restriction.

Description

Copyright © 2009 American Chemical Society

Locate the Document

https://doi.org/10.1021/ja906981w

DOI

10.1021/ja906981w

Persistent Identifier

https://archives.pdx.edu/ds/psu/32395

Citation Details

Plush, S. E., Woods, M., Zhou, Y.-F., Kadali, S. B., Wong, M. S., & Sherry, A. D. (2009). Nanoassembled capsules as delivery vehicles for large payloads of high relaxivity Gd3+ agents. Journal Of The American Chemical Society, 131(43), 15918–15923. https://doi.org/10.1021/ja906981w