Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents
The authors thank the National Institutes of Health (RR-02584, CA-126608, and CA-115531), the Robert A Welch Foundation (AT-584), 3M (NTF Award), the National Science Foundation (CBET-0652073), Portland State University, Oregon Opportunity, and the Kobayashi Graduate Student Fellowship (to S.B.K.) for financial assistance. We also thank both the MCIF and flow cytometry core facilities and Professor Gao’s research group at UT Southwestern Medical Center for valuable discussions.
Journal of the American Chemical Society
Nanoassembled capsules (NACs) that incorporate a polymer aggregate inside a silica shell may be loaded with agents that are of particular interest for therapeutic or diagnostic applications. NACs formed using the MRI contrast agent GdDOTP5− in the internal polymer aggregate are reported herein, the smaller of which show promise as potential MRI contrast agents. Unlike many other nanoencapsulated systems, water access to the inner core of these NACs does not appear to be limited and consequently the water relaxivity per Gd3+ agent can reach as high as 24 mM−1 s−1. Robust, spherical capsules were formed using polyallylamine or poly-l-lysine ranging from 0.2 to 5 μm in diameter. The greatest gains in relaxivity were observed for smaller NACs, for which water accessibility remained high but molecular rotation of the Gd3+ chelate was effectively restricted. Larger NACs did not afford such large gains in relaxivity, the result of poorer water accessibility combined with less-effective rotational restriction.
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Plush, S. E., Woods, M., Zhou, Y.-F., Kadali, S. B., Wong, M. S., & Sherry, A. D. (2009). Nanoassembled capsules as delivery vehicles for large payloads of high relaxivity Gd3+ agents. Journal Of The American Chemical Society, 131(43), 15918–15923. https://doi.org/10.1021/ja906981w