Title

Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents

Published In

Journal of the American Chemical Society

Document Type

Citation

Publication Date

2010

Abstract

Nanoassembled capsules (NACs) that incorporate a polymer aggregate inside a silica shell may be loaded with agents that are of particular interest for therapeutic or diagnostic applications. NACs formed using the MRI contrast agent GdDOTP5− in the internal polymer aggregate are reported herein, the smaller of which show promise as potential MRI contrast agents. Unlike many other nanoencapsulated systems, water access to the inner core of these NACs does not appear to be limited and consequently the water relaxivity per Gd3+ agent can reach as high as 24 mM−1 s−1. Robust, spherical capsules were formed using polyallylamine or poly-l-lysine ranging from 0.2 to 5 μm in diameter. The greatest gains in relaxivity were observed for smaller NACs, for which water accessibility remained high but molecular rotation of the Gd3+ chelate was effectively restricted. Larger NACs did not afford such large gains in relaxivity, the result of poorer water accessibility combined with less-effective rotational restriction.

Description

Copyright © 2009 American Chemical Society

Locate the Document

https://doi.org/10.1021/ja906981w

DOI

10.1021/ja906981w

Persistent Identifier

https://archives.pdx.edu/ds/psu/32395

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