Sponsor
Financial support from the National Institutes of Health (CA115531, RR02584, and EB04285) and the Robert A. Welch Foundation (AT-584) is gratefully acknowledged.
Published In
Journal of the American Chemical Society
Document Type
Post-Print
Publication Date
10-22-2008
Subjects
Magnetic resonance imaging, Ligands (Biochemistry) -- Polymerization, Contrast media (Diagnostic imaging) -- Synthesis
Abstract
Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
DOI
https://dx.doi.org/10.1021/ja805775u
Persistent Identifier
https://archives.pdx.edu/ds/psu/32567
Citation Details
Wu, Y., Zhou, Y., Ouari, O., Woods, M., Zhao, P., Soesbe, T. C., ... & Sherry, A. D. (2008). Polymeric PARACEST agents for enhancing MRI contrast sensitivity. Journal of the American Chemical Society, 130(42), 13854-13855.
Description
This is the authors version of a paper that subsequently appeared in the Journal of the American Chemical Society, vol. 130, no. 42: 13854–13855. The version of record may be found at https://dx.doi.org/10.1021/ja805775u.
Note: At the time of writing Mark Woods was affiliated with the University of Texas at Dallas.