Financial support from the National Institutes of Health (CA115531, RR02584, and EB04285) and the Robert A. Welch Foundation (AT-584) is gratefully acknowledged.
Journal of the American Chemical Society
Magnetic resonance imaging, Ligands (Biochemistry) -- Polymerization, Contrast media (Diagnostic imaging) -- Synthesis
Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
Wu, Y., Zhou, Y., Ouari, O., Woods, M., Zhao, P., Soesbe, T. C., ... & Sherry, A. D. (2008). Polymeric PARACEST agents for enhancing MRI contrast sensitivity. Journal of the American Chemical Society, 130(42), 13854-13855.