Sponsor
Financial assistance from the Swiss National Science Foundation (A.B.); the EU COST Action D18 “Lanthanide Chemistry for Diagnosis and Therapy” (L.M.); the Hughes Undergraduate Research Fellows Program (J.F.B.); the National Institutes of Health (CA-91597 and RR-01811, R.B.C.), (EB-04285, M.W.), (CA-115531 and RR-02584, A.D.S.); the Petroleum Research Fund
Published In
Chemistry - A European Journal
Document Type
Post-Print
Publication Date
3-7-2008
Subjects
Relaxation (Nuclear physics), Gadolinium, Contrast media (Diagnostic imaging) -- Synthesis, Magnetic resonance imaging, Macrocyclic compounds, Ligands (Biochemistry)
Abstract
Electron‐spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. One of the reasons for the poor understanding of electron‐spin relaxation is that it is closely related to the ligand‐field parameters of the Gd3+ ion that forms the basis of MRI contrast agents and these complexes generally exhibit a structural isomerism that inherently complicates the study of electron spin relaxation. We have recently shown that two DOTA‐type ligands could be synthesised that, when coordinated to Gd3+, would adopt well defined coordination geometries and are not subject to the problems of intramolecular motion of other complexes. The EPR properties of these two chelates were studied and the results examined with theory to probe their electron‐spin relaxation properties
DOI
10.1002/chem.200701747
Persistent Identifier
https://archives.pdx.edu/ds/psu/32581
Citation Details
Borel, A., Bean, J. F., Clarkson, R. B., Helm, L., Moriggi, L., Sherry, A. D., & Woods, M. (2008). Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium (III)–DOTA‐Type Complexes. Chemistry–A European Journal, 14(9), 2658-2667.
Description
This is the pre-peer reviewed version of the following article: Borel, A., Bean, J. F., Clarkson, R. B., Helm, L., Moriggi, L., Sherry, A. D., & Woods, M. (2008). Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium (III)–DOTA‐Type Complexes. Chemistry–A European Journal, 14(9), 2658-2667, which has been published in final form at https://doi.org/10.1002/chem.200701747. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Note: At the time of writing Mark Woods was affiliated with the University of Texas at Dallas.