Lanthanide Metal-Organic Frameworks for Multispectral Radioluminescent Imaging
Published In
Acs Applied Materials & Interfaces
Document Type
Citation
Publication Date
6-17-2020
Abstract
In this report, we describe the X-ray luminescent properties of two lanthanide-based nanoscale metal–frameworks (nMOFs) and their potential as novel platforms for optical molecular imaging techniques such as X-ray excited radioluminescence (RL) imaging. Upon X-ray irradiation, the nMOFs display sharp tunable emission peaks that span the visible to near-infrared spectral region (∼400–700 nm) based on the identity of the metal (Eu, Tb, or Eu/Tb). Surface modification of the nMOFs with polyethylene glycol (PEG) resulted in nanoparticles with enhanced aqueous stability that demonstrated both cyto- and hemo-compatibility important prerequisites for biological applications. Importantly, this is the first report to document and investigate the radioluminescent properties of lanthanide nMOFs. Taken together, the observed radioluminescent properties and low in vitro toxicity demonstrated by the nMOFs render them promising candidates for in vivo translation.
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DOI
10.1021/acsami.0c06010
Persistent Identifier
https://archives.pdx.edu/ds/psu/33970
Citation Details
Neufeld, M. J., Winter, H., Landry, M. R., Goforth, A. M., Khan, S., Pratx, G., & Sun, C. (2020). Lanthanide Metal–Organic Frameworks for Multispectral Radioluminescent Imaging. ACS Applied Materials & Interfaces, 12(24), 26943–26954. https://doi.org/10.1021/ACSAMI.0C06010
Description
© 2020 American Chemical Society