Fluorogenic Probes for Thioredoxin Reductase Activity

Authors

Tendai J. Mafireyi, Portland State University
Jorge O. Escobedo, Portland State UniversityFollow
Robert Strongin, Portland State UniversityFollow

Sponsor

Funding: This work was supported by Portland State University.

Published In

Results in Chemistry

Document Type

Article

Publication Date

4-16-2021

Subjects

Fluorescence microscopy, Fluorine compounds, Fluorescent probes

Abstract

The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH. Various methods have been developed for the detection and quantification of the thioredoxin reductase enzyme. Most of these methods suffer the shortfall of poor specificity, hence there is need to develop more robust and specific techniques. Recently, there has been an increased interest in fluorescent probes that can target thioredoxin reductase. This review highlights the progress in the synthesis and application of the different fluorescent probes that have been employed for this purpose.

Rights

© 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Locate the Document

https://doi.org/10.1016/j.rechem.2021.100127

DOI

10.1016/j.rechem.2021.100127

Persistent Identifier

https://archives.pdx.edu/ds/psu/35303

Citation Details

Mafireyi, T. J., Escobedo, J. O., & Strongin, R. M. (2021). Fluorogenic probes for thioredoxin reductase activity. Results in Chemistry, 100127.