Sponsor
This article is a collaborative project by the Center for Coordination of Analytics, Science, Enhancement and Logistics (CASEL) in Tobacco Regulatory Science Toxicity Special Interest Group (SIG), which is supported, in part, by the CASEL cooperative agreement U54DA046060-01 (National Institute of Drug Abuse (NIDA) and the Food and Drug Administration’s Center for Tobacco Products (FDA CTP). AEH, AA, TLW and MCB report support from the National Cancer Institute (NCI) (grant number U54CA287392). HCE reports support from NIDA (grant number U54DA036151). IR reports support from NCI (grant number U54CA228110). RS reports support from the National Institute of Environmental Health Sciences (grant number R01ES025257). IS reports support from NIDA (grant number U01DA045523).
Published In
Tobacco Induced Diseases
Document Type
Article
Publication Date
4-2024
Subjects
Vaping Machines, Vaping -- toxicity, Electronic cigarettes -- Health aspects
Abstract
In this narrative review, we highlight the challenges of comparing emissions from different tobacco products under controlled laboratory settings (using smoking/ vaping machines). We focus on tobacco products that generate inhalable smoke or aerosol, such as cigarettes, cigars, hookah, electronic cigarettes, and heated tobacco products. We discuss challenges associated with sample generation including variability of smoking/vaping machines, lack of standardized adaptors that connect smoking/vaping machines to different tobacco products, puffing protocols that are not representative of actual use, and sample generation session length (minutes or number of puffs) that depends on product characteristics. We also discuss the challenges of physically characterizing and trapping emissions from products with different aerosol characteristics. Challenges to analytical method development are also covered, highlighting matrix effects, order of magnitude differences in analyte levels, and the necessity of tailored quality control/quality assurance measures. The review highlights two approaches in selecting emissions to monitor across products, one focusing on toxicants that were detected and quantified with optimized methods for combustible cigarettes, and the other looking for productspecific toxicants using non-targeted analysis. The challenges of data reporting and statistical analysis that allow meaningful comparison across products are also discussed. We end the review by highlighting that even if the technical challenges are overcome, emission comparison may obscure the absolute exposure from novel products if we only focus on relative exposure compared to combustible products.
Rights
Copyright (c) 2024 The Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
Locate the Document
DOI
10.18332/tid/183797
Persistent Identifier
https://archives.pdx.edu/ds/psu/41749
Citation Details
El-Hellani, A., Adeniji, A., Erythropel, H. C., Wang, Q., Lamb, T., Mikheev, V. B., ... & Brinkman, M. C. (2024). Comparison of emissions across tobacco products: A slippery slope in tobacco control. Tobacco Induced Diseases, 22.