Sponsor
This study is a cross-institution collaborative project from the Toxicity Special Interest Group (SIG) supported, in part, by the Center for Coordination of Analytics, Science, Enhancement and Logistics (CASEL) in Tobacco Regulatory Science U54DA046060 (National Institute of Drug Abuse (NIDA) and the Food and Drug Administration’s Center for Tobacco Products (FDA CTP). Support for authors was also provided by NIDA and FDA CTP awards R01ES025257 (RMS and DHP), U54DA036151 (HCE), U54DA036105, R03ES029441-02S1 (AN), U54 CA228110 (IR), T30IR0894 (NOFK) and U54DA046060-01 (ES).
Published In
Tobacco Control
Document Type
Article
Publication Date
4-24-2024
Subjects
Vaping Machines, Vaping -- toxicity, Electronic cigarettes -- Health aspects
Abstract
Studies of Electronic Nicotine Delivery Systems (ENDS) toxicity have largely focused on individual components such as flavour additives, base e-liquid ingredients (propylene glycol, glycerol), device characteristics (eg, model, components, wattage), use behaviour, etc. However, vaping involves inhalation of chemical mixtures and interactions between compounds can occur that can lead to different toxicities than toxicity of the individual components. Methods based on the additive toxicity of individual chemical components to estimate the health risks of complex mixtures can result in the overestimation or underestimation of exposure risks, since interactions between components are under-investigated. In the case of ENDS, the potential of elevated toxicity resulting from chemical reactions and interactions is enhanced due to high operating temperatures and the metallic surface of the heating element. With the recent availability of a wide range of e-liquid constituents and popularity of do-it-yourself creation of e-liquid mixtures, the need to understand chemical and physiological impacts of chemical combinations in ENDS e-liquids and aerosols is immediate. There is a significant current knowledge gap concerning how specific combinations of ENDS chemical ingredients result in synergistic or antagonistic interactions. This commentary aims to review the current understanding of chemical reactions between e-liquid components, interactions between additives, chemical reactions that occur during vaping and aerosol properties and biomolecular interactions, all of which may impact physiological health.
Rights
© Author(s) (or their employer(s)) 2024. Re- use permitted under CC BY- NC. No commercial re- use. See rights and permissions. Published by BMJ.
Locate the Document
DOI
10.1136/tc-2023-058546
Persistent Identifier
https://archives.pdx.edu/ds/psu/41823
Citation Details
Strongin, R. M., Sharma, E., Erythropel, H. C., Kassem, N. O. F., Noël, A., Peyton, D. H., & Rahman, I. (2024). Chemical and physiological interactions between e-liquid constituents: cause for concern? Tobacco Control, tc-2023-058546.