Published In
JACS Au
Document Type
Article
Publication Date
6-24-2024
Subjects
Vaping Machines, Vaping -- toxicity, Electronic cigarettes -- Health aspects
Abstract
Ketene is one of the most toxic vaping emissions identified to date. However, its high reactivity renders it relatively challenging to identify. In addition, certain theoretical studies have shown that realistic vaping temperature settings may betoo low to produce ketene. Each of these issues is addressed herein. First, an isotopically labeled acetate precursor is used for the identification of ketene with enhanced rigor in vaped aerosols. Second, discrepancies between theoretical and experimental findings are explained by accounting for the effects of aerobic (experimental) versus anaerobic (simulated and theoretical) pyrolysis conditions. This finding is also relevant to explaining the relatively low-temperature production of aerosol toxicants beyond ketene. Moreover, the study presented herein shows that ketene formation during vaping is not limited to molecules possessing a phenyl acetate substructure. This means that ketene emission during vaping, including from popular flavorants such as ethyl acetate, may be more prevalent than is currently known.
Rights
Copyright © 2024 The Authors. Published by American Chemical Society. This publication is licensed under
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DOI
10.1021/jacsau.4c00436
Persistent Identifier
https://archives.pdx.edu/ds/psu/42221
Citation Details
Munger, K. R., Anreise, K. M., Jensen, R. P., Peyton, D. H., & Strongin, R. M. (2024). Mechanistic Rationale for Ketene Formation during Dabbing and Vaping. JACS Au, 4(6), 2403–2410.