Origins of Fine Structure in DNA Melting Curves

Published In

Journal of Chemical Physics

Document Type

Citation

Publication Date

8-7-2024

Abstract

With the help of the one-dimensional random Potts-like model, we study the origins of fine structures observed on differential melting profiles of double-stranded DNA. We theoretically assess the effects of sequence arrangement on DNA melting curves through the comparison of results for random, correlated, and block sequences. Our results re-confirm the smearing out of the fine structure with the increase in chain length for all types of sequence arrangements and suggest that the fine structure is a finite-size effect. We have found that the fine structures on melting curves of chains comprised of blocks with correlations in sequence are more persistent, probably because of increased sequence disorder the blocks introduce. Many natural DNAs show a well-expressed fine structure of melting profiles. Our results for block sequences may suggest the existence of such sequence motifs in natural DNA sequences.

Rights

© Copyright 2024 AIP Publishing LLC

Locate the Document

https://doi.org/10.1063/5.0213526

DOI

10.1063/5.0213526

Persistent Identifier

https://archives.pdx.edu/ds/psu/42557

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