Sponsor
Funded by the Office of Research in Women's Health and the National Institute of Child Health and Human Development, Oregon BIRCWH Award Number K12HD043488-01 (JBH). KLT is supported by 2PO1HD34430 and the OHSU Edwards Endowment.
Published In
Preventive Medicine
Document Type
Post-Print
Publication Date
12-2015
Subjects
Obesity physiopathology, Chronic diseases -- Etiology
Abstract
Prenatal development is recognized as a critical period in the etiology of obesity and cardiometabolic disease. Potential strategies to reduce maternal obesity-induced risk later in life have been largely overlooked. In this paper, we first propose a conceptual framework for the role of public health and preventive medicine in mitigating the effects of fetal programming. Second, we review a small but growing body of research (through August 2015) that examines interactive effects of maternal obesity and two public health foci – diet and physical activity – in the offspring. Results of the review support the hypothesis that diet and physical activity after early life can attenuate disease susceptibility induced by maternal obesity, but human evidence is scant. Based on the review, we identify major gaps relevant for prevention research, such as characterizing the type and dose response of dietary and physical activity exposures that modify the adverse effects of maternal obesity in the offspring. Third, we discuss potential implications of interactions between maternal obesity and postnatal dietary and physical activity exposures for interventions to mitigate maternal obesity-induced risk among children. Our conceptual framework, evidence review, and future research directions offer a platform to develop, test, and implement fetal programming mitigation strategies for the current and future generations of children.
DOI
10.1016/j.ypmed.2015.10.012
Persistent Identifier
http://archives.pdx.edu/ds/psu/17071
Citation Details
Boone-Heinonen, J., Messer, L. C., Fortmann, S. P., Wallack, L., & Thornburg, K. L. (2015). From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity. Preventive Medicine.
Description
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International License.
This is the author accepted manuscript for an article subsequently published by Elsevier. The definitive version can be found on the publisher website.