Published In
World Journal of Diabetes
Document Type
Article
Publication Date
11-2023
Subjects
Diabetes, Diabetes -- Treatment, Behavior modification, Blood sugar monitoring
Abstract
Dementia is a prevalent condition in type 2 diabetes mellitus (T2DM) patients. While Chinese herbal medicine (CHM) is often employed as complementary therapy for glycemic control, its effect in controlling likelihood of dementia has not yet been fully elucidated. AIM To compare the risk of dementia between T2DM patients with and without CHM treatment. METHODS We undertook a nested case-control study and obtained data on patients 20-70 years of age who received medical care for T2DM between 2001 and 2010 from the National Health Insurance Research database in Taiwan. Cases, defined as those with dementia that occurred at least one year after the diagnosis of T2DM, were randomly matched to controls without dementia from the study cohort at a 1:1 ratio. We applied conditional logistic regression to explore the associations between CHM treatment and dementia. RESULTS A total of 11699 dementia cases were matched to 11699 non-dementia controls. We found that adding CHM to conventional care was related to a lower risk of dementia [adjusted odds ratio (OR) = 0.51], and high-intensity CHM treatment was associated with an adjusted OR of 0.22. CONCLUSION This study shows that the cumulative CHM exposure was inversely associated with dementia risk in an exposureresponse manner, implying that CHM treatment may be embraced as a disease management approach for diabetic patients to prevent dementia.
Rights
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Locate the Document
DOI
10.4239/wjd.v14.i11.1632
Persistent Identifier
https://archives.pdx.edu/ds/psu/41039
Citation Details
Citation: Liao HH, Livneh H, Huang HL, Hung JY, Lu MC, Guo HR, Tsai TY. Reduced risk of dementia in patients with type 2 diabetes mellitus using Chinese herbal medicine: A nested case-control study. World J Diabetes 2023; 14(11): 1632-1642 URL: https://www.wjgnet.com/1948-9358/full/v14/i11/1632.htm DOI: https://dx.doi.org/10.4239/wjd.v14.i11.1632