Sponsor
This work was supported in part by the Murdock Foundation, Portland, Oregon, and the Whitaker Foundation, Washington, D.C.
Published In
Optical Engineering
Document Type
Article
Publication Date
8-1-1998
Subjects
Cavitation, Bubbles, Drug delivery systems, Lasers, Ultrashort laser pulses
Abstract
Pulsed laser ablation of blood clots in a fluid-filled blood vessel is accompanied by an explosive evaporation process. The resulting vapor bubble rapidly expands and collapses to disrupt the thrombus (blood clot). The hydrodynamic pressures following the bubble expansion and collapse can also be used as a driving force to deliver clot-dissolving agents into thrombus for enhancement of laser thrombolysis. Thus, the laser-induced bubble formation plays an important role in the thrombus removal process. We investigate the effects of boundary configurations and materials on bubble formation with time-resolved flash photography and high-speed photography. Potential applications in drug delivery using microsecond laser pulses are also discussed.
Rights
Copyright 1998 Society of Photo-Optical Instrumentation Engineers.
DOI
10.1117/1.601738
Persistent Identifier
http://archives.pdx.edu/ds/psu/8237
Citation Details
Shangguan, H, Casperson, LW, Paisley, DL, Prahl, SA, (1998). Photographic studies of laser-induced bubble formation in absorbing liquids and on submerged targets: implications for drug delivery with microsecond laser pulses. Opt. Eng. 0001;37(8):2217-2226.