Sponsor
This work was sponsored in part by National Institutes of Health grant R21CA103824.
Published In
Optics Express
Document Type
Article
Publication Date
11-27-2006
Subjects
Speckle, Nondestructive testing, Optical coherence tomography, Imaging systems
Abstract
We present two approaches to speckle tracking for optical coherence tomography (OCT)-based elastography, one appropriate for small speckle motions and the other for large, rapid speckle motions. Both approaches have certain advantages over traditional cross-correlation based motion algorithms. We apply our algorithms to quantifying the strain response of a mechanically inhomogeneous, bi-layered polyvinyl alcohol tissue phantom that is subjected to either small or large dynamic compressive forces while being imaged with a spectral domain OCT system. In both the small and large deformation scenarios, the algorithms performed well, clearly identifying the two mechanically disparate regions of the phantom. The stiffness ratio between the two regions was estimated to be the same for the two scenarios and both estimates agreed with the expected stiffness ratio based on earlier mechanical testing. No single numerical approach is appropriate for all cases and the experimental conditions dictate the proper choice of speckle shift algorithm for OCT-based elastography studies.
DOI
10.1364/OE.14.011585
Persistent Identifier
http://archives.pdx.edu/ds/psu/7285
Citation Details
Sean J. Kirkpatrick, Ruikang K. Wang, and Donald D. Duncan, "OCT-based elastography for large and small deformations," Opt. Express 14, 11585-11597 (2006)
Description
This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/oe/viewmedia.cfm?uri=oe-14-24-11585&seq=0. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.