We gratefully acknowledge the support of the Wallace H. Coulter Foundation through the Early Career Award for Translational Research.
Image processing -- Digital techniques, Optical data processing
We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO2 ~0.95 and venous SO2 ~ 0.5.
Jessica C. Ramella-Roman, Scott A. Mathews, Haripriya Kandimalla, Afshin Nabili, Donald D. Duncan, Salvatore A. D'Anna, Syed M. Shah, and Quan D. Nguyen, "Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera," Opt. Express 16, 6170-6182 (2008)