Sponsor
This research was supported in part by the Murdock Foundation, Portland, Ore., and the Whitaker Foundation, Washington, D.C.
Published In
Applied Optics
Document Type
Article
Publication Date
7-1-1996
Subjects
Drug delivery devices -- Research, Cavitation, Bubbles -- Dynamics, Laser ablation
Abstract
Photo acoustic drug delivery is a technique for localized drug delivery by laser-induced hydrodynamic pressure following cavitation bubble expansion and collapse. Photoacoustic drug delivery was investigated on gelatin-based thrombus models with planar and cylindrical geometries by use of one microsecond laser pulses. Solutions of a hydrophobic dye in mineral oil permitted monitoring of delivered colored oil into clear gelatin-based thrombus models. Cavitation bubble development and photoacoustic drug delivery were visualized with flash photography. This study demonstrated that cavitation is the governing mechanism for photoacoustic drug delivery, and the deepest penetration of colored oil in gels followed the bubble collapse. Spatial distribution measurements revealed that colored oil could be driven a few millimeters into the gels in both axial and radial directions, and the penetration was less than 500 µm when the gelatin structure was not fractured.
DOI
10.1364/AO.35.003347
Persistent Identifier
http://archives.pdx.edu/ds/psu/8140
Citation Details
HanQun Shangguan, Lee W. Casperson, Alan Shearin, Kenton W. Gregory, and Scott A. Prahl, "Drug delivery with microsecond laser pulses into gelatin," Appl. Opt. 35, 3347-3357 (1996).
Description
This paper was published in Applied Optics and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-35-19-3347. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.