First Advisor

Bradley Buckley

Date of Award

2015

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Biology and University Honors

Department

Biology

Subjects

Laboratory animals -- Effect of stress on, Animal experimentation, Stress (Physiology), Animal welfare

DOI

10.15760/honors.128

Abstract

Historically, animals have been used in medical research to bring about many of the medical breakthroughs and advances seen today. The successful studies are accompanied by numerous, often concealed, failed studies that are inapplicable to human medicine due to stress and distress changing the "normal" physiological parameters of that animal. The psychological stresses observed on the research animals are numerous and include habitat inconsistencies, exposures to abnormal conditions, experimental stresses, and the anticipation of awaiting a procedure. Often published papers disguise these conditions with delicate terminology to eliminate question of error in their data. When an animal is mentally, or physically stressed, the animal’s physiology is altered. The changes in an animal’s physiology due to psychological stress may change the efficacy of the research in ways that may render the research inapplicable to human medicine studies. The three R’s of animal research (Replacement, Reduction, and Refinement) has become the guide for future technologies in medical research without the use of animal models.

Rights

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Persistent Identifier

http://archives.pdx.edu/ds/psu/15390

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