First Advisor

Mark Woods

Date of Award

3-1-2018

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Biology and University Honors

Department

Biology

Subjects

Contrast media (Diagnostic imaging), Zinc, Chelates, Magnetic resonance imaging

DOI

10.15760/honors.521

Abstract

Current contrast agents are Gd3+-based, which successfully enhance MRI images but are limited in detecting certain analytes compared to new agents that operate through a CEST mechanism. In this study, a Eu3+ and Tm3+ chelate were examined as CEST agents for MRI imaging in four concentrations of zinc: 0, 0.5, 1, and 2 equivalents. T1 values were obtained using NMR spectrometry, which were then used to fit the data to obtain CEST spectra for the compounds. The CEST spectra of the Tm3+ chelate had a shift in the amide protons as Zn2+ concentrations increased indicating a presence of multiple species and a change in coordination chemistry. The change of the amide peak at -52 ppm showed its potential to be used as a marker for Zn2+ concentration. The Eu³⁺ chelate was useful for examining CEST arising from the coordinated water. A distinct change in the water peak shape, intensity, and shift was observed as Zn²⁺ was added, showing increased water exchange kinetics

Rights

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Persistent Identifier

http://archives.pdx.edu/ds/psu/24260

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