Bachelor of Science (B.S.) in Biology and University Honors
Jeffrey D. Robinson, Ph.D.
Abstract: Uncontrolled type 1 diabetes puts adolescents at an increased risk for cardiovascular disease, retinopathy, neuropathy, reduced brain mass, and reduced life expectancy among other symptoms. Clinically, behavioral interventions are staged for patients with uncontrolled type 1 diabetes. Meta-analyses of these interventions have yielded non-significant differences in overall glycemic control, and have yet to identify any significant moderators of outcomes. The goal of this study was to update and improve upon past meta-analyses, and evaluate potential moderators. 28 RCTs of behavioral interventions in type 1 diabetes evaluating glycemic control were identified. Variables within interventions were collected and reviewed systematically, separating interventions into groups based on operational intensity, and time investment. Significant differences in effect size between groups separated by intervention administrator, training of administrators, and contact time were observed, marking those variables as potential effect moderators. However, more stringent meta-analytic tests concluded no evidence for moderation by any of the identified variables. Future studies regarding the science of intervention development should aim to limit demographic variance, and identify articles with large sample sizes, in order to discover significant moderators in improving glycemic control within behavioral type 1 diabetes interventions.
Larsen, Christopher E. Mr., "Interventions in Type 1 Diabetes: A Systematic Review and Meta-Analysis Examining Factors that Lead to Improved Glycemic Control" (2019). University Honors Theses. Paper 756.
Available for download on Monday, June 14, 2021