This study has been conducted with the support of the Korea Institute of Industrial Technology as “Development of controllable mechanical and biological properties scaffold based on additive manufacturing (KITECH JE-22-0012)”.
Biomaterial, Scaffold, Additive manufacturing, Material property, Property tailoring
Polycaprolactone (PCL) has been one of the most popular biomaterials in tissue engineering due to its relatively low melting temperature, excellent thermal stability, and cost-effectiveness. However, its low cell attraction, low elastic modulus, and long-term degradation time have limited its application in a wide range of scaffold studies. Dimethyl sulfone (DMSO2) is a stable and non-hazardous organosulfur compound with low viscosity and high surface tension. PCL and DMSO2 composites may overcome the limitations of PCL as a biomaterial and tailor the properties of biocomposites. In this study, PCL and DMSO2 composites were investigated as a new bio-scaffold material to increase hydrophilicity and mechanical properties and tailor degradation properties in vitro. PCL and DMSO2 were physically mixed with 10, 20, and 30 wt% of DMSO2 to evaluate thermal, hydrophilicity, mechanical, and degradation properties of the composites. The water contact angle of the composites for hydrophilicity decreased by 15.5% compared to pure PCL. The experimental results showed that the mechanical and degradation properties of PCL and DMSO2 were better than those of pure PCL, and the properties can be tuned by regulating DMSO2 concentration in the PCL matrix. The elastic modulus of the composite with 30 wt% of DMSO2 showed 532 MPa, and its degradation time was 18 times faster than that of PCL.
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
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Jang, J.-W.; Min, K.-E.; Kim, C.; Wern, C.; Yi, S. PCL and DMSO2 Composites for Bio-Scaffold Materials. Materials 2023, 16, 2481. https://doi.org/10.3390/ ma16062481