Sponsor
Portland State University. Environmental Sciences and Resources Ph. D. Program
First Advisor
Jonathan J. Abramson
Term of Graduation
Spring 1993
Date of Publication
5-5-1993
Document Type
Dissertation
Degree Name
Doctor of Philosophy (Ph.D.) in Environmental Sciences and Resources: Physics
Department
Environmental Sciences and Resources
Language
English
Subjects
Calcium channels, Sarcoplasmic reticulum, Calcium in the body
DOI
10.15760/etd.1306
Physical Description
1 online resource (5, xii, 171 pages)
Abstract
The sarcoplasmic reticulum (SR) is an intracellular membrane system dedicated to the active regulation of cytosolic calcium in muscle. The opening of Ca²⁺ channels in the SR results in a rapid increase in the myoplasmic Ca²⁺ concentration and the initiation of contraction. Closure of these channels allows the SR to re-accumulate the released Ca²⁺ which results in muscle relaxation. While it is known that a muscle fiber is stimulated to contract by the depolarization of the sarcolemma, it is not understood how this signal is communicated to the SR.
The focus of this dissertation is twofold. The first objective is to gain an understanding of the mechanism of Ca²⁺ release from the SR. To this end, three studies have been performed which indicate that Ca²⁺ release is mediated by an oxidation reaction. The second goal is to gain insight into the function of the Ca²⁺ release channel. This is addressed by a fourth study which characterizes the effect of the plant alkaloid, ryanodine on channel operation.
Rights
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
Persistent Identifier
https://archives.pdx.edu/ds/psu/4364
Recommended Citation
Buck, Edmond, "Mechanism of Calcium Release From Skeletal Muscle Sarcoplasmic Reticulum" (1993). Dissertations and Theses. Paper 1307.
https://doi.org/10.15760/etd.1306
Comments
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