Portland State University. Department of Chemistry
Date of Award
Master of Science (M.S.) in Chemistry
1 online resource (50 p.)
Hemerythrin, Proteins, Thiols, Binding sites (Biochemistry)
Hemerythrin is a respiratory protein found in the erythrocytes of certain marine invertebrates. Structures have been obtained by x-ray crystallography for hemerythrins from Phascolopsis gouldii (P. gouldii) and Themiste dyscritum (T. dyscritum). Since many proteins are inactivated upon binding heavy metals such as mercury, an investigation of mercury-protein interactions in this protein was undertaken. In order to understand the nature of heavy-metal protein interactions in T. dyscritum it was necessary to identify the metalloprotein ligands since neither the liganding amino acid residues nor the geometry of the mercury complexes could be identified in the crystallographic studies.
Clarke, Suzanne Elizabeth, "Involvement of Hemerythrin Sulfhydryl Groups in Heavy Atom Binding and Subunit Interactions" (1977). Dissertations and Theses. Paper 2473.