First Advisor

Lester J. Newman

Date of Publication

1983

Document Type

Thesis

Degree Name

Master of Science (M.S.) in Biology

Department

Biology

Language

English

Subjects

Mosaicism, Down syndrome

DOI

10.15760/etd.5284

Physical Description

1 online resource (116 p.)

Abstract

Down Syndrome is a human condition caused by an extra copy of a #21 chromosome. At least one to two percent of free (not translocated) trisomy 21 cases are mosaics, i.e., they have two or more distinct cell lines. Usually, one cell line is 47 ,XX or XY ,+21 while the other cell line is normal 46,XX or 46,XY.

The purpose of the study was to establish the etiologies of the separate cell lines by determining whether the zygote was trisomic or normal. Meiotic non-disjunction in the formation of a gamete could lead to a trisomic zygote; loss of a #21 chromosome during a later mitotic division could then lead to a chromosomally normal cell line. Alternatively, a mitotic error in a normal embryo can produce a trisomy 21 cell line.

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Comments

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Persistent Identifier

http://archives.pdx.edu/ds/psu/19292

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