Sponsor
Portland State University. Department of Chemistry
First Advisor
Dirk Iwata-Reuyl
Term of Graduation
Winter 2022
Date of Publication
3-3-2022
Document Type
Thesis
Degree Name
Master of Science (M.S.) in Chemistry
Department
Chemistry
Language
English
Subjects
Catalytic RNA, Aerosol propellants, Life -- Origin, Self-assembly (Chemistry)
DOI
10.15760/etd.7804
Physical Description
1 online resource (v, 45 pages)
Abstract
Recent theoretical and experimental work suggests that aqueous aerosols in the early Earth's atmosphere might have been an essential component to the development of life. These complex droplets would have served to compartmentalize emerging biomolecules, thereby concentrating them, increasing reactivity, and facilitating transport and exchange between ocean and atmosphere. This project tests an underexplored but potentially important environmental paradigm for the RNA world hypothesis of prebiotic evolution, probing the effects of aerosolization on catalytic RNA using a model ribozyme. Here we demonstrate the successful transport and in situ self-assembly of the Azoarcus ribozyme from multiple independent fragments via a laboratory-constructed aerosolization system.
Rights
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Persistent Identifier
https://archives.pdx.edu/ds/psu/37416
Recommended Citation
Farrell, Brennan Roland, "Aerosolization of Catalytic RNA for Prebiotic Transport and In Situ Reactivity" (2022). Dissertations and Theses. Paper 5933.
https://doi.org/10.15760/etd.7804