Portland State University. Department of Chemistry
Term of Graduation
Date of Publication
Master of Science (M.S.) in Chemistry
Catalytic RNA, Aerosol propellants, Life -- Origin, Self-assembly (Chemistry)
1 online resource (v, 45 pages)
Recent theoretical and experimental work suggests that aqueous aerosols in the early Earth's atmosphere might have been an essential component to the development of life. These complex droplets would have served to compartmentalize emerging biomolecules, thereby concentrating them, increasing reactivity, and facilitating transport and exchange between ocean and atmosphere. This project tests an underexplored but potentially important environmental paradigm for the RNA world hypothesis of prebiotic evolution, probing the effects of aerosolization on catalytic RNA using a model ribozyme. Here we demonstrate the successful transport and in situ self-assembly of the Azoarcus ribozyme from multiple independent fragments via a laboratory-constructed aerosolization system.
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Farrell, Brennan Roland, "Aerosolization of Catalytic RNA for Prebiotic Transport and In Situ Reactivity" (2022). Dissertations and Theses. Paper 5933.