Designing Ethical Trials of Germline Gene Editing
Published In
The New England Journal of Medicine
Document Type
Citation
Publication Date
11-16-2017
Abstract
The recent announcement that researchers have successfully used the CRISPR (clustered regularly interspaced short palindromic repeats) gene-editing technique to correct a mutation that leads to hypertrophic cardiomyopathy in human embryos is the latest reminder of the urgency of the social and ethical issues surrounding potential clinical use of gene editing. Clinical use in humans is still far off; much research is needed to determine whether germline gene editing can be done safely and with acceptable risks; the legal and regulatory status of the technology varies widely around the world. Nevertheless, the drastic reduction in rates of off-target effects and mosaicism in the recent study — only 2 years since the first such experiment on human embryos was announced — shows how quickly the technology is progressing.
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DOI
10.1056/NEJMp1711000
Persistent Identifier
https://archives.pdx.edu/ds/psu/25872
Citation Details
Cwik, B. (2017). Designing Ethical Trials of Germline Gene Editing. New England Journal of Medicine, 377(20), 1911-1913.