Sponsor
This work was supported by the Cystic Fibrosis Foundation (BESWIC20A0, BESWIC22Y5; https://www.cff.org/) awarded to DMB.
Published In
Plos One
Document Type
Article
Publication Date
9-26-2024
Subjects
Chronic rhinosinusitis, Sinus surgery outcome assessment (healthcare), Cytokine -- Biomarker
Abstract
Introduction Cystic fibrosis (CF) is commonly complicated by chronic rhinosinusitis (CRS). Despite highly effective management options, CRS in people with CF (PwCF+CRS) may be refractory to medical therapy, eventually requiring endoscopic sinus surgery. The impact of sinus surgery on pulmonary, quality of life (QOL), and other outcomes in PwCF+CRS in the expanding era of highly effective modulator therapy has not been fully elucidated. This study aims to determine if endoscopic sinus surgery can offer superior outcomes for PwCF+CRS when compared to continued medical treatment of CRS. Methods and analysis This multi-institutional, observational, prospective cohort study will enroll 150 adults with PwCF+CRS across nine US CF Centers who failed initial medical therapy for CRS and elected to pursue either endoscopic sinus surgery or continue medical treatment. To determine if sinus surgery outperforms continued medical therapy in different outcomes, we will assess changes in pulmonary, CF-specific QOL, CRS-specific QOL, sleep quality, depression, headache, cognition, olfaction, productivity loss, and health utility value after treatment. The influence of highly effective modulator therapy on these outcomes will also be evaluated. This study will provide crucial insights into the impact of endoscopic sinus surgery for PwCF+CRS and aid with development of future treatment pathways and guidelines.
Rights
Copyright: © 2024 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Locate the Document
DOI
10.1371/journal.pone.0310986
Persistent Identifier
https://archives.pdx.edu/ds/psu/42680
Citation Details
Liu, C. M., Fischer, J. L., Alt, J. A., Bodner, T. E., Chowdhury, N. I., Getz, A. E., Hwang, P. H., Kimple, A. J., Mace, J. C., Smith, T. L., Soler, Z. M., Goss, C. H., Taylor-Cousar, J. L., Saavedra, M. T., & Beswick, D. M. (2024). Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study. PLOS ONE, 19(9), e0310986.