Sponsor
This work was supported by the National Institute on Aging at the National Institutes of Health (Grant Number: R01AG055681 and RF1AG058545 to ARQ). Additional funding: National Institute on Aging/National Institutes of Health (R01AG047891) to HGA. The funders played no role in the in the study design, data collection and analysis, decision to publish, or preparation of this manuscript.
Published In
Plos One
Document Type
Article
Publication Date
7-10-2025
Subjects
Comorbidity, Chronic diseases -- Etiology
Abstract
Patterns of development of cardiometabolic multimorbidity (CMM) and the impact of specific cardiometabolic disease combinations on cognitive function are not well understood. This study utilizes sequence analysis to describe the ordering and timing of cardiometabolic disease accumulation over a five-year period and to assess both sociodemographic predictors and cognitive outcomes of typical cardiometabolic disease sequences.
Rights
Copyright: © 2025 Nagel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Locate the Document
DOI
10.1371/journal.pone.0326309
Persistent Identifier
https://archives.pdx.edu/ds/psu/43968
Publisher
Public Library of Science (PLoS)
Citation Details
Nagel, C. L., Chen, S., Allore, H. G., Botoseneanu, A., Newsom, J. T., Bishop, N., Dorr, D. A., Kaye, J., & Quiñones, A. R. (2025). Longitudinal sequencing of cardiometabolic multimorbidity among older adults and association with subsequent dementia onset. PLOS One, 20(7), e0326309.