Sponsor
The Partners PrEP Ancillary Adherence Study and the Partners PrEP Study were both supported by the Bill and Melinda Gates Foundation (grants 47674 and OOP52516).
Published In
Journal of Acquired Immune Deficiency Syndromes
Document Type
Post-Print
Publication Date
5-2015
Subjects
HIV-positive persons -- Sexual behavior, HIV infections -- Risk factors, HIV infections -- Social aspects, HIV infections -- Reporting
Physical Description
15 pages
Abstract
Objective—To assess the role of sexual relationships on levels and patterns of adherence to medication for pre-exposure prophylaxis (PrEP) against HIV.
Methods—We enrolled 1,147 HIV-negative individuals in long-term serodiscordant relationships at three sites in Uganda from the Partners PrEP Study- a randomized placebo-controlled trial of daily oral tenofovir and emtricitabine/tenofovir. We used generalized estimation equations to assess the effects of sexual relationships on low adherence (
Results—Fifty-three percent were male, 51% were 18-34 years and 24% were polygamous. Participants who reported sex in the past month with someone other than their primary partner and with
Conclusions—Risk of low overall adherence was higher in participants who reported sex outside primary partnerships and suboptimal condom use, as well as in those who abstained from sex. Adherence gaps were common, potentially creating risk for HIV acquisition.
DOI
10.1097/QAI.0000000000000538
Persistent Identifier
http://archives.pdx.edu/ds/psu/18631
Publisher
Lippincott, Williams & Wilkins
Citation Details
Kintu A, Hankinson SE, Balasubramanian R, Ertel K, Tumwesigye E, Bangsberg DR, Haberer JE. Sexual Relationships Outside Primary Partnerships and Abstinence Are Associated With Lower Adherence and Adherence Gaps: Data From the Partners PrEP Ancillary Adherence Study. J Acquir Immune Defic Syndr. 2015 May 1; 69(1):36-43
Description
Author's version of a paper that subsequently appeared in the Journal of Acquired Immune Deficiency Syndromes, 2015 May 1; 69(1): 36–43. doi:10.1097/QAI.0000000000000538. Published by Lippincott, Williams & Wilkins.
At the time of writing, David Bangsberg was affiliated with Harvard School of Public Health, Massachusetts General Hospital and Harvard Medical School.