Presentation Type
Oral Presentation
Start Date
5-8-2024 9:00 AM
End Date
5-8-2024 11:00 AM
Subjects
Chemistry, Magnetic resonance imaging
Advisor
Mark Woods
Student Level
Doctoral
Abstract
Gadolinium chelates have found widespread application as contrast agents in Magnetic Resonance Imaging (MRI) a cornerstone in modern medical diagnostics. In recent years two significant challenges have emerged to the use of Gd3+ chelates in MRI:
- The safety of these Gd3+-based agents, specifically related to the possible in vivo release of Gd3+.
- The environmental impact of anthropogenic Gd3+ pollution of surface waters arising from using contrast agents.
The escalating reports of Gd3+ presence in environmental matrices, and its adverse effects on marine life and human health, necessitate urgent intervention to mitigate consequential environmental and health risks.
Aryl substitution of the popular contrast agent GdDOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may provide solutions to these challenges. A deracemization reaction permits a wide range of substituents to be introduced into the chelate framework. In this presentation, we will explore the effect of different substituents on several key properties of substituted chelates. These include deracemization extent, the ratio of SAP/TSAP isomers, and water-exchange kinetics. Additionally, we will examine their effects on contrast agent efficacy, the potential for reducing dosage, and the kinetic robustness of these agents in vivo. Lastly, examine methods for selectively intercepting contrast agents before wastewater treatment to combat anthropogenic Gd3+ pollution.
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Persistent Identifier
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Included in
Exploring The Potential Of α-Aryl Substitution Of GdDOTA To Address Challenges Associated With MRI Contrast Agents.
Gadolinium chelates have found widespread application as contrast agents in Magnetic Resonance Imaging (MRI) a cornerstone in modern medical diagnostics. In recent years two significant challenges have emerged to the use of Gd3+ chelates in MRI:
- The safety of these Gd3+-based agents, specifically related to the possible in vivo release of Gd3+.
- The environmental impact of anthropogenic Gd3+ pollution of surface waters arising from using contrast agents.
The escalating reports of Gd3+ presence in environmental matrices, and its adverse effects on marine life and human health, necessitate urgent intervention to mitigate consequential environmental and health risks.
Aryl substitution of the popular contrast agent GdDOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may provide solutions to these challenges. A deracemization reaction permits a wide range of substituents to be introduced into the chelate framework. In this presentation, we will explore the effect of different substituents on several key properties of substituted chelates. These include deracemization extent, the ratio of SAP/TSAP isomers, and water-exchange kinetics. Additionally, we will examine their effects on contrast agent efficacy, the potential for reducing dosage, and the kinetic robustness of these agents in vivo. Lastly, examine methods for selectively intercepting contrast agents before wastewater treatment to combat anthropogenic Gd3+ pollution.