Thrasher Research Fund
Brain damage -- Computer simulation, Intracranial pressure -- Measurement, Clinical trials -- Computer simulation
This report documents a computer model of intracranial pressure (ICP) dynamics that is used to evaluate clinical treatment options for elevated ICP during traumatic brain injury (TBI). The model uses fluid volumes as primary state variables and explicitly models fluid flows as well as the resistance, compliance, and pressure associated with each of the compartments (arteries and arterioles, capillary bed, veins, venous sinus, ventricles, and brain parenchyma). The model has been tested to assure that it reproduces a correct physiologic response to intra-and extra-parenchymal hemorrhage and edema, and to therapies directed at reducing ICP such as cerebral spinal fluid drainage, mannitol administration, head elevation, and mild hyperventilation.
The model is able to replicate observed clinical behavior in many cases, including elevated ICP associated with severe cerebral edema, subdural hematoma, and cerebrospinal fluid blockage. The model also successfully reproduces tne cerebrovascular regulatory mechanisms that are activated during TBI in response to various abnormalities such as high or low systemic blood pressure.
We conclude that incorporating fluid volumes and flows into a model of lCP dynamics significantly improved its clinical utility. Additional improvements are anticipated (or wil1 accrue or will result) as the specific mechanisms that modify cerebral compliance and autoregulation during TBI and elevated ICP are further delineated.
Wakeland, Wayne W.; Goldstein, Brahm; Macovsky, Louis; and McNames, James, "A Computer Model of Intracranial Pressure Dynamics During Traumatic Brain Injury that Explicitly Models Fluid Flows and Volumes" (2003). Systems Science Faculty Publications and Presentations. 19.