Published In
Frontiers in Bioengineering and Biotechnology
Document Type
Article
Publication Date
8-12-2022
Subjects
Traumatic brain injuries, Brain Injuries -- diagnosis
Abstract
Traumatic brain injury (TBI) is a highly complex phenomenon involving a cascade of disruptions across biomechanical, neurochemical, neurological, cognitive, emotional, and social systems. Researchers and clinicians urgently need a rigorous conceptualization of brain injury that encompasses nonlinear and mutually causal relations among the factors involved, as well as sources of individual variation in recovery trajectories. System dynamics, an approach from systems science, has been used for decades in fields such as management and ecology to model nonlinear feedback dynamics in complex systems. In this mini-review, we summarize some recent uses of this approach to better understand acute injury mechanisms, recovery dynamics, and care delivery for TBI. We conclude that diagram-based approaches like causal-loop diagramming have the potential to support the development of a shared paradigm of TBI that incorporates social support aspects of recovery. When developed using adequate data from large-scale studies, simulation modeling presents opportunities for improving individualized treatment and care delivery.
Rights
Copyright (c) 2022 The Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
Locate the Document
DOI
10.3389/fbioe.2022.854358
Persistent Identifier
https://archives.pdx.edu/ds/psu/38484
Citation Details
Kenzie, E. S., Parks, E. L., Carney, N., & Wakeland, W. (2022). System dynamics modeling for traumatic brain injury: Mini-review of applications. Frontiers in bioengineering and biotechnology, 1333.