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Submissions from 2014

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The Presence of Fast-Exchanging Proton Species in Aqueous Solutions of paraCEST Agents Can Impact Rate Constants Measured for Slower Exchanging Species When Fitting CEST Spectra to the Bloch Equations, Osasere M. Evbuomwan, Joohwan Lee, Mark Woods, and A. Dean Sherry

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The Impact of Surface Ligands and Synthesis Method on the Toxicity of Glutathione-Coated Gold Nanoparticles, Bryan Harper, Federico Sinche, Meenambika Gowrishankar, Grant Marquart, Marilyn R. Mackiewicz, and Stacey L. Harper

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Serial Transfer Can Aid the Evolution of Autocatalytic Sets, Wim Hordijk, Nilesh Vaidya, and Niles Lehman

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A Facile Route to Tailoring Peptide-Stabilized Gold Nanoparticles Using Glutathione as a Synthon, Rosina Ho Wu, Tan P. Nguyen, Grant W. Marquart, Thomas J. Miesen, Theresa Mau, and Marilyn R. Mackiewicz

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The Atmosphere can be a Source of Certain Water Soluble Volatile Organic Compounds in Urban Streams, Scott J. Kenner, David A. Bender, James F. Pankow, and John S. Zogorski

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Photocatalytic Hydrogen Production from a Noble Metal Free System Based on a Water Soluble Porphyrin Derivative and a Cobaloxime Catalyst, Theodore Lazarides, Milan Delor, Igor V. Sazanovich, Theresa M. McCormick, Irene Georgakaki, Georgios Charalambidis, Julia A. Weinstein, and Athanassios G. Coutsolelos

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Empirical Demonstration of Environmental Sensing in Catalytic RNA: Evolution of Interpretive Behavior at the Origins of Life, Niles Lehman, Tess Bernhard, Brian C. Larson, Andrew J.N. Robinson, and Christopher C.B. Southgate

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Reducing the Effects of Shot Noise Using Nanoparticles, Moshood K. Morakinyo and Shankar B. Rananavare

The Effect of Regioisomerism on the Coordination Chemistry and CEST Properties of lanthanide(III) NB-DOTA-Tetraamide Chelates, Jacqueline R. Slack and Mark Woods

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Inhalable Constituents of Thirdhand Tobacco Smoke: Chemical Characterization and Health Impact Considerations, Mohamad Sleiman, Jennifer M. Logue, Wentai Luo, James F. Pankow, Lara A. Gundel, and Hugo Destaillats

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The Confluence of Structure and Dynamics in Lanthanide(III) Chelates: How Dynamics Help Define Structure in Solution, Benjamin Charles Webber and Mark Woods

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Human Whole-Blood (1)H2O Longitudinal Relaxation With Normal and High-Relaxivity Contrast Reagents: Influence of Trans-Cell-Membrane Water Exchange, Gregory J. Wilson, Mark Woods, Charles S. Springer Jr., Sarah Bastawrous, Puneet Bhargava, and Jeffrey H. Maki

Submissions from 2013

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Analysis of Small Molecule Ligands Targeting the HIV-1 Matrix Protein-RNA Binding Site, Ayna Alfadhli, Henry McNett, Jacob Eccles, Seyram Tsagli, Colleen Noviello, Rachel Sloan, Claudia S. López, David H. Peyton, and Eric Barklis

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Coupling Fast Water Exchange to Slow Molecular Tumbling in Gd3+ Chelates: Why Faster Is Not Always Better, Stefano Avedano, Mauro Botta, Julian Saunders Haigh, Dario L. Lango, and Mark Woods

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Aqueous Red-Emitting Silicon Nanoparticles for Cellular Imaging: Consequences of Protecting Against Surface Passivation by Hydroxide and Water for Stable Red Emission, Sheng-Kuei Chiu, Beth Ann Manhat, William J.I. DeBenedetti, Anna L. Brown, Katye Fichter, Tania Vu, Micah Eastman, Jun Jiao, and Andrea Mitchell Goforth

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Partitioning the Fitness Components of RNA Populations Evolving In Vitro, Carolina Diaz Arenas and Niles Lehman

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Evolution of Multispectral Aerosol Optical Properties in a Biogenically-Influenced Urban Environment During the CARES Campaign, Madhu Gyawali, W. Patrick Arnott, Rahul A. Zaveri, C. Song, Mikhail Pekour, B. Flowers, Manvendra K. Dubey, Ari Setyan, Qi Zhang, Joseph Harworth, James Gregory Radney, Dean B. Atkinson, S. China, Claudio Mazzoleni, Kyle Gorkowski, R. Subramanian, B. Tom Jobson, and Hans Moosmüller

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Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds, Takatoshi Karasawa, Martha Sibrian-Vazquez, Robert M. Strongin, and Peter S. Steyger

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Picture of a Chelate in Exchange: The Crystal Structure of NaHoDOTMA, a 'Semi'-Hydrated Chelate, Katherine M. Payne, Edward J. Valente, Silvio Aime, Mauro Botta, and Mark Woods

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Allosteric Mechanism of Water Channel Gating by Ca2+–calmodulin, Steve Reichow, Daniel M. Clemens, J. Alfredo Freites, Karin L. Németh-Cahalan, Matthias Heyden, Douglas J. Tobias, James E. Hall, and Tamir Gonen

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The Dynamic Modulation of Water Permeability in the Lens Aquaporin-0, Steve L. Reichow and Tamir Gonen

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Robust Visible Light Photoswitching with Ortho-Thiol Substituted Azobenzenes, Subhas Samanta, Theresa M. McCormick, Simone K. Schmidt, Dwight S. Seferos, and G. Andrew Woolley

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Intrinsic Disorder within an AKAP-protein Kinase A Complex Guides Local Substrate Phosphorylation, F. Donelson Smith, Steve L. Reichow, Jessica L. Esseltine, Dan Shi, Lorene K. Langeberg, John D. Scott, and Tamir Gonen

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Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio), Phillip M. Uribe, Melissa A. Mueller, Julia S. Gleichman, Matthew D. Kramer, Qi Wang, Martha Sibrian-Vazquez, Robert M. Strongin, Peter S. Steyger, Douglas A. Cotanche, and Jonathan I. Matsui

Submissions from 2012

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Differential Effects of the Hydrophobic Surfactant Proteins on the Formation of Inverse Bicontinuous Cubic Phases, Mariya Chavarha, Ryan W. Loney, Kamlesh Kumar, Shankar B. Rananavare, and Stephen B. Hall

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A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma, Yixing Guo, Xiaofeng Yang, Lovemore Hakuna, Aabha Barve, Jorge O. Escobedo, Mark Lowry, and Robert M. Strongin

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The Chemical Origin of Behavior is Rooted in Abiogenesis, Brian C. Larson, R. Paul Jensen, and Niles Lehman

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Evolution Finds Shelter in Small Spaces, Niles Lehman

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Advanced Nanohybrid Materials: Surface Modification and Applications, Li-Hung Liu, Rémi Métivier, Shanfeng Wang, and Hui Wang

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Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria, David H. Peyton

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Functional Promiscuity of the COG0720 Family, Gabriela Phillips, Laura L. Grochowski, Shilah Bonnett, Huimin Xu, Marc Bailly, Crysten Haas-Blaby, Basma El Yacoubi, Dirk Iwata-Reuyl, Robert H. White, and Valérie de Crécy-Lagard

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Diversity of Archaeosine Synthesis in Crenarchaeota, Gabriela Phillips, Manal A. Swairjo, Kirk W. Gaston, Marc Bailly, Patrick A. Limbach, Dirk Iwata-Reuyl, and Valérie de Crécy-Lagard

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Surfactant-Free Hybridization of Transition Metal Oxide Nanoparticles With Conductive Graphene for High-Performance Supercapacitor, Wen Qian, Zhiqiang Chen, Steven Cottingham, William Alexander Merrill, Natasja A. Swartz, Andrea Mitchell Goforth, Tami Lasseter Clare, and Jun Jiao

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Progress toward red and near-infrared (NIR) emitting saccharide sensors, Martha Sibrian-Vazquez, Jorge O. Escobedo, Mark Lowry, and Robert M. Strongin

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Thiol Reactive Probes and Chemosensors, Robert M. Strongin, Lovemore Hakuna, Hanjing Peng, Weixuan Chen, Yunfeng Cheng, and Binghe Wang

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Chemical Exchange Saturation Transfer is Unaffected by Modest Changes in Pressure, Benjamin Charles Webber, Christiane A. Carney, and Mark Woods

Structural Analysis of Isomeric Europium(III) Chelates of NB-DOTMA, Benjamin Charles Webber and Mark Woods

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A Seminaphthofluorescein-Based Fluorescent Chemodosimeter for the Highly Selective Detection of Cysteine, Xiaofeng Yang, Yixing Guo, and Robert M. Strongin

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Overview of the 2010 Carbonaceous Aerosols and Radiative Effects Study (CARES), Rahul A. Zaveri, William J. Shaw, Daniel J. Cziczo, Beat Schmid, Richard Ferrare, M. Lizabeth Alexander, Raul Alvarez, W. Patrick Arnott, Dean B. Atkinson, Sunil Baidar, Robert M. Banta, James Barnard, Josef Beranek, Larry K. Berg, Fred Brechtel, W. Alan Brewer, John F. Cahill, Brian Cairns, Christopher D. Cappa, D. Chand, S. China, Jennifer M. Comstock, Manvendra K. Dubey, Robert C. Easter, M. H. Erickson, Jerome Fast, Cody Floerchinger, B. Flowers, Edward C. Fortner, Jeffrey S. Gaffney, Mary K. Gilles, Kyle Gorkowski, William Gustafson, Madhu Gyawali, J. Hair, R. M. Hardesty, Joseph Harworth, Scott C. Herndon, Naruki Hiranuma, Chris Hostetler, John M. Hubbe, John T. Jayne, H. Jeong, B. Tom Jobson, Evgueni Kassianov, Lawrence I. Kleinman, C. Kluzek, W. Berk Knighton, Katheryn R. Kolesar, Chongai Kuang, Alena Kubátová, Andrew O. Langford, Alexander Laskin, N. Laulainen, Richard D. Marchbanks, Claudio Mazzoleni, Fan Mei, Ryan C. Moffet, Dan Nelson, Michael Obland, Hilke Oetjen, Timothy B. Onasch, I. Ortega, Matteo Ottaviani, Mikhail Pekour, Kimberly A. Prather, James Gregory Radney, Raymond R. Rogers, Scott P. Sandberg, Arthur J. Sedlacek, Christoph J. Senff, Gunnar I. Senum, Ari Setyan, John E. Shilling, ManishKumar Shrivastava, C. Song, Stephen R. Springston, R. Subramanian, Kaitlyn Suski, Jason Tomlinson, Rainer M. Volkamer, H. W. Wallace, Jian Wang, A. M. Weickmann, Douglas R. Worsnop, Xiao-Ying Yu, Alla Zelenyuk, and Qi Zhang

Submissions from 2011

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Properties, Solution State Behavior, and Crystal Structures of Chelates of DOTMA, Silvio Aime, Mauro Botta, Zoltán Garda, Benjamin E. Kucera, Gyula Tircso, Victor Young, and Mark Woods

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Tension Directly Stabilizes Reconstituted Kinetochore-Microtubule Attachments, Bungo Akiyoshi, Krishna K. Sarangapani, Andrew F. Powers, Christian R. Nelson, Steve Reichow, Hugo Arellano-Santoyo, Tamir Gonen, Jeffrey A. Ranish, Charles L. Asbury, and Sue Biggins

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HIV-1 Matrix Protein Binding to RNA, Ayna Alfadhli, Henry McNett, Seyram Tsagli, Hans Peter Bachinger, and David H. Peyton

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Competition for hydrogen-bond formation in the helix-coil transition and protein folding, A. V. Badasyan, S. A. Tonoyan, Y. S. Mamasakhlisov, A. Giacometti, Albert S. Benight, and V. F. Morozov

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Towards the Rational Design of MRI Contrast Agents: δ-Substitution of Lanthanide(III) NB-DOTA-Tetraamide Chelates Influences but Does Not Control Coordination Geometry, Christiane E. Carney, Anh D. Tran, Jing Wang, Matthias C. Schabel, A. Dean Sherry, and Mark Woods

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AKAP2 Anchors PKA with Aquaporin-0 to Support Ocular Lens Transparency, Matthew G. Gold, Steve Reichow, Susan E. O'Neill, Chad R. Weisbrod, Lorene K. Langeberg, James E. Bruce, Tamir Gonen, and John D. Scott

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Organometallic Iron(III)-Salophene Exerts Cytotoxic Properties in Neuroblastoma Cells via MAPK Activation and ROS Generation, Kyu Kwang Kim, Rakesh K. Singh, Robert M. Strongin, Richard G. Moore, Laurent Brard, and Thilo S. Lange

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Detecting Specific Saccharides via a Single Indicator, Soojin Lim, Jorge O. Escobedo, Mark Lowry, and Robert M. Strongin

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Imaging the Extracellular pH of Tumors by MRI after Injection of a Single Cocktail of T1 and T2 Contrast Agents, Gary V. Martinez, Xiaomeng Zhang, María L. García-Martín, David L. Morse, Mark Woods, A. Dean Sherry, and Robert J. Gillies

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Positional Control Over Nanoparticle Deposition into Nanoholes, Moshood K. Morakinyo and Shankar B. Rananavare

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The Binding of the Cholera Toxin to the Periplasmic Vestibule of the Type II Secretion Channel, Steve Reichow, Konstantin V. Korotkov, Melissa Gonen, Ji Sun, Jaclyn R. Delarosa, Wim GJ Hol, and Tamir Gonen

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Analysis of the Conformational Behavior and Stability of the SAP and TSAP Isomers of Lanthanide(III) NB-DOTA-Type Chelates, Gyula Tircso, Benjamin Charles Webber, Benjamin E. Kucera, Victor G. Young, and Mark Woods

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Bis Photobase Generator, Hoang Tran and Shankar B. Rananavare

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Synthesis and Characterization of N- and P- Doped Tin Oxide Nanowires, Hoang Tran and Shankar B. Rananavare

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Strategies for Labeling Proteins with PARACEST Agents, Olga Vasalatiy, Piyu Zhao, Mark Woods, Andrei Marconescu, Aminta Castillo-Muzquiz, Philip Thorpe, Garry Kiefer, and A. Dean Sherry

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Advances in Structural and Functional Analysis of Membrane Proteins by Electron Crystallography, Goragot Wisedchaisri, Steve Reichow, and Tamir Gonen

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Investigations Into Whole Water, Prototropic and Amide Proton Exchange in Lanthanide(III) DOTA-Tetraamide Chelates, Mark Woods, Azhar Pasha, Piyu Zhao, Gyula Tircso, Somdatta Chowdhury, Garry Kiefer, Donald E. Woessner, and A. Dean Sherry

LDL-Based Nanoparticles for Contrast Enhanced MRI of Atheroplaques in Mouse Models, Yoko Yamakoshi, Hui Qiao, Andrew N. Lowell, Mark Woods, Betty Paulose, Yuka Nakao, Hualei Zhang, Ting Liu, Sissel Lund-Katz, and Rong Zhou

Submissions from 2010

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Comparison of in Situ and Columnar Aerosol Spectral Measurements during TexAQS-GoMACCS 2006: Testing Parameterizations for Estimating Aerosol Fine Mode Properties, Dean B. Atkinson, Paola Massoli, Norman T. O'Neill, Patricia K. Quinn, Sarah D. Brooks, and Barry Lefer

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Microscopic formulation of the Zimm-Bragg model for the helix-coil transition, A. V. Badasyan, A. Giacometti, Y. S. Mamasakhlisov, V. F. Morozov, and Albert S. Benight

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Facile Pyrolytic Synthesis of Silicon Nanowires, Joo C. Chan, Hoang Tran, James W. Pattison, and Shankar B. Rananavare

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Quasispecies-Like Behavior Observed in Catalytic RNA Populations Evolving in a Test Tube, Carolina Diaz Arenas and Niles Lehman

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NIR Dyes for Bioimaging Applications, Jorge O. Escobedo, Oleksandr Rusin, Soojin Lim, and Robert M. Strongin

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CEST and PARACEST MR Contrast Agents, Ileana Hancu, W. Thomas Dixon, Mark Woods, Elena Vinogradov, A. Dean Sherry, and Robert E. Lenkinski

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Bandwidth tuning triggers interplay of charge order and superconductivity in two-dimensional organic materials, S. Kaiser, M. Dressel, Y. Sun, A. Greco, J. A. Schlueter, Gary L. Gard, and N. Drichko

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Complexity Through Recombination: From Chemistry to Biology, Niles Lehman, Carolina Diaz Arenas, Wesley A. White, and Francis J. Schmidt

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Selective Fluorescence Detection of Cysteine and N-Terminal Cysteine Peptide Residues, Soojin Lim, Jorge O. Escobedo, Mark Lowry, Xiangyang Xu, and Robert M. Strongin

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Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity, Yuan Liu, Christopher Hazzard, Alessandra S. Eustáquio, Kevin A. Reynolds, and Bradley S. Moore

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Cooperative Interaction of Transcription Termination Factors with the RNA Polymerase II C-terminal Domain, Bradley M. Lunde, Steve Reichow, Minkyu Kim, Hyunsuk Suh, Thomas C. Leeper, Fan Yang, Hannes Mutschler, Stephen Buratowski, Anton Meinhart, and Gabriele Varani

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C - Reactive Protein Induced Rearrangement of Phosphatidylcholine on Nanoparticle Mimics of Lipoprotein Particles, Marilyn R. Mackiewicz, Heather L. Hodges, and Scott M. Reed

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The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates Is Substantially Affected by Solvent, Kyle J. Miller, Ali A. Saherwala, Benjamin C. Webber, Yunkou Wu, A. Dean Sherry, and Mark Woods

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Copper Thin-Film Dissolution/Precipitation Kinetics in Organic HF Containing Cleaning Solution, Nabil George Mistkawi, Makarem A. Hussein, Malgorzata Ziomek-Moroz, and Shankar B. Rananavare

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Corrosion Behavior of Copper Thin Films in Organic HF-Containing Cleaning Solution for Semiconductor Applications, Nabil George Mistkawi, Makarem A. Hussein, Malgorzata Ziomek-Moroz, and Shankar B. Rananavare

Minimizing Formaldehyde Use in the Synthesis of Gold−Silver Core−Shell Nanoparticles, Christopher B. Norris, Paul R. Joseph, Marilyn R. Mackiewicz, and Scott M. Reed

Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents, Sally E. Plush, Mark Woods, You-Fu Zhou, Shyam B. Kadali, Michael S. Wong, and A. Dean Sherry

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Structure of the Cholera Toxin Secretion Channel in Its Closed State, Steve Reichow, Konstantin V. Korotkov, Wim GJ Hol, and Tamir Gonen

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Homocystamides promote free-radical and oxidative damage to proteins, Martha Sibrian-Vazquez, Jorge O. Escobedo, Soojin Lim, George K. Samoei, and Robert M. Strongin

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Scoring Function to Predict Solubility Mutagenesis, Ye Tian, Christopher Deutsch, and Bala Krishnamoorthy

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Extensive Aerosol Optical Properties and Aerosol Mass Related Measurements During TRAMP/TexAQS 2006 – Implications for PM Compliance and Planning, Monica Elizabeth Wright, Dean B. Atkinson, Luke Ziemba, Robert Griffin, Naruki Hiranuma, Sarah D. Brooks, James Flynn, Ryan Perna, Bernhard Rappenglück, Winston Luke, and Paul Kelley

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Polymeric PARACEST MRI Contrast Agents as Potential Reporters for Gene Therapy, Yunkou Wu, Christiane E. Carney, Michael Denton, Elaine Hart, Piyu Zhao, Daniel N. Streblow, A. Dean Sherry, and Mark Woods

Submissions from 2009

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Structural Basis for Binding Specificity Between Subclasses of Modular Polyketide Synthase Docking Domains, Tonia Buchholz, Todd W. Geders, Frank E. Bartley III, Kevin A. Reynolds, Janet L. Smith, and David H. Sherman

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DNA Before Proteins? Recent Discoveries in Nucleic Acid Catalysis Strengthen the Case, Aaron Steven Burton and Niles Lehman

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Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis, Shuchi Gupta, Venkatraman Lakshmanan, Beom Seok Kim, Robert Fecik, and Kevin A. Reynolds

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Solid State and Solution Dynamics of Pyridine Based Tetraaza- Macrocyclic Lanthanide Chelates Possessing Phosphonate Ligating Functionality (Ln-PCTMB): Effect on Relaxometry and Optical Properties, Garry Kiefer and Mark Woods

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Apoptotic and Chemotherapeutic Properties of Iron (III)-Salophene in an Ovarian Cancer Animal Model, Thilo S. Lange, Carolyn McCourt, Rakesh K. Singh, Kyu Kwang Kim, Ajay P. Singh, Brian S. Luisi, Onur Alptürk, Robert M. Strongin, and Laurent Brard

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Effect of the Regiochemistry of Butyl Amide Substituents on the Solution-State Structures of Lanthanide(III) DOTA-Tetraamide Complexes, Tomoyasu Mani, Gyula Tircsó, Piyu Zhao, A. Dean Sherry, and Mark Woods

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Synthesis and Evaluation of Lanthanide Ion DOTA-tetraamide Complexes bearing Peripheral Hydroxyl Groups, Azhar Pasha, Mai Lin, Gyula Tircso, Cynthia L. Rostollan, Mark Woods, Garry Kiefer, A. Dean Sherry, and Xiankai Sun

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Lipid-protein Interactions Probed by Electron Crystallography, Steve L. Reichow and Tamir Gonen

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Optimising the Synthesis and Red–Green–Blue Emission of a Simple Organic Dye, Martha Sibrian-Vazquez and Robert M. Strongin

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One RNA Plays Three Roles to Provide Catalytic Activity to a Group I Intron Lacking an Endogenous Internal Guide Sequence, Nilesh Vaidya and Niles Lehman

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Exploring the pH Dependence of Viologen Reduction by Alpha-Carbon Radicals Derived from HCy and Cys, Dong Wang, William E. Crowe, Robert M. Strongin, and Martha Sibrian-Vazquez

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A Photochemically Initiated Chemistry for Coupling Underivatized Carbohydrates to Gold Nanoparticles, Xin Wang, Olof Ramström, and Mingdi Yan

Submissions from 2008

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Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent, M. Meser Ali, Mark Woods, Peter Caravan, Ana C.L. Opina, Marga Spiller, James C. Fettinger, and A. Dean Sherry

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Electron Crystallography of Aquaporins, Simeon Andrews, Steve Reichow, and Tamir Gonen

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Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)–DOTA-Type Complexes, Alain Borel, Jonathan F. Bean, Robert B. Clarkson, Lothar Helm, Loïck Moriggi, A. Dean Sherry, and Mark Woods

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Electrical Detection of the Temperature Induced Melting Transition of a DNA Hairpin Covalently Attached to Gold Interdigitated Microelectrodes, Greg P. Brewood, Yaswanth Rangineni, Daniel J. Fish, Ashwini Bhandiwad, David R. Evans, Raj Solanki, and Albert S. Benight

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Synthesis and Characterization of Novel Chiral Ionic Liquids and Investigation of their Enantiomeric Recognition Properties, David K. Bwambok, Hadi M. Marwani, Vivian E. Fernand, Sayo O. Fakayode, Mark Lowry, Ioan Negulescu, Robert M. Strongin, and Isiah M. Warner

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Discrete Sums for the Rapid Determination of Exponential Decay Constants, Michael A. Everest and Dean B. Atkinson

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An Embarrassment of Riches: The Enzymology of RNA Modification, Dirk Iwata-Reuyl

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Iron(III)-Salophene: An Organometallic Compound with Selective Cytotoxic and Anti-Proliferative Properties in Platinum-Resistant Ovarian Cancer Cells, Thilo S. Lange, Kyu Kwang Kim, Rakesh K. Singh, Robert M. Strongin, Carolyn McCourt, and Laurent Brard

Reversible, Reagentless Solubility Changes in Phosphatidylcholine-stabilized Gold Nanoparticles, Marilyn R. Mackiewicz, Benjamin Robert Ayres, and Scott M. Reed